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Conclusion: In our primary analysis, we did not observe a significantly different risk of MOF between treatment with GLP-1RA and DPP-4i
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First, absolute incidence: in the pooled STEP 1 to 3 obesity trials of semaglutide 2.4 mg (the Wegovy weight-management dose), constipation affected 24.2% of patients versus 11.1% on placebo , alongside nausea (43.9%), diarrhoea (29.7%), and vomiting (24.5%)
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