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In animal models, GLP-1RAs inhibited myocardial fibrosis and reduced ventricular hypertrophy.21 Antiarrhythmic Properties GLP-1RAs may lower the risk of AF, a common comorbidity in HF that worsens prognosis, by reducing the volume of epicardial fat, modulating calcium handling within cardiomyocytes and improving left atrial remodelling.22โ24 Natriuretic and Diuretic Effects GLP-1RAs promote natriuresis and diuresis
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So we call them insufficient responders or poor responders