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An 8-week phase 1 multiple ascending dose (MAD) study was conducted on healthy individuals with body mass index (BMI) 18–28 kg/m 2 at doses of 450 mcg for 4 weeks (cohort 1), 900 mcg for 4 weeks (cohort 2), and an 8-week dose escalation up to 1,520 mcg (cohort 3) (41)
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