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In January 2020, Ozempic was also approved "to reduce the risk of major cardiovascular events such as heart attack, stroke or death in adults with type 2 diabetes mellitus with known heart disease." In December 2020, Novo Nordisk applied with the FDA to gain approval for a once-weekly 2.4 mg injection of semaglutide for weight management
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In the trial mentioned above, one year after stopping the GLP-1 medication, participants also saw: Blood pressure levels go back up C-reactive protein levels (an indicator of inflammation) increase VLDL cholesterol (a type that leads to hardened arteries) goes up Triglycerides (a type of blood fat) go up Hemoglobin A1c increases (meaning the level of sugar in the blood) At high levels, these health markers are associated with conditions like type 2 diabetes, obesity, hypertension, and heart disease, to list a few
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